Charlie Girl's Laugh out loud funny plot summary is hands down the best thing I've read about Transamerica:
Bree: I'm about to have SRS, but somehow I never learned to do makeup properly. My lipstick covers most of the lower half of my face. I'm twitchy and neurotic, and correct people on their grammar and punctuation. Oh, and I have no friends.
Toby (via telephone): Hi, I'm the son you never knew you had. Come bail me out.
Therapist: Hi, my name is Doctor Plot Device. Every time you refuse to follow the plot of the movie, I'm going to threaten to withhold permission for your SRS. You must go have a wacky cross-country roadtrip, or no SRS for you!
Bree: Why do I have to have an oddball buddy comedy roadtrip before I can have SRS? Is that in the Harry Benjamin standards or something?
Therapist: No, it's just the plot of the movie. Now go do it, or else.